Tech Tips (by ALLDATA): Mercedes key won’t turn in ignition
TECH TIPS (courtesy of ALLDATA)
Vehicle: 2004 Mercedes Benz S 430 (220.170), V8-4.3L (113.941), Automatic Transmission
Mileage: 199,776
Problem: The vehicle was towed in because the key would not turn on the Electronic Ignition Switch (EIS).

Details: The technician attempted to communicate with the EIS, it was not possible. At that point, he called Tech-Assist.
The Tech-Assist consultant studied the wiring diagram and found a possible problem. In the Power Distribution diagram, fuse #78 in the Cockpit Fuse Box powers the EIS itself (see the wiring diagram below).
The technician inspected fuse #78 and found that it was cracked.
Confirmed Repair: He replaced the fuse and that repaired the problem.